Work

Increased cortical serotonin-2 (5-HT-2) receptors in the iminodipropionitrile (IDPN)-model of persistent dyskinesia in the rat

Year: 1987

Type: article

Abstract: Chronic treatment with IDPN causes a persistent behavioral syndrome which is reminiscent of the head shakes, backward locomotion, and hyperactivity observed after acute injection of 5-HT agonists in rodents. Evaluation of the characteristics of 5-HT receptors, using mianserin to label 5-HT-2 receptors, revealed a significant increase in the number of binding sites in the cortices of rats which demonstrated the IDPN-induced syndrome. There was an associated decrease in the affinity of the receptors. These results add more evidence to support the idea that the serotonergic system may play a significant role in the manifestation of the persistent abnormalities induced by IDPN.

Source: Neuropeptides

DOI: 10.1016/0143-4179(87)90019-9

Authors: Jean Lud Cadet, Richard B. Rothman

Institutions: Columbia University Irving Medical Center, Columbia University, St. Elizabeths Hospital

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,530