Work

Lipid rafts and T‐lymphocyte function: Implications for autoimmunity

Year: 2008

Type: article

Abstract: Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T-lymphocytes, lipid rafts are implicated in signalling from the T-cell antigen receptor (TCR) and in localization and function of proteins residing proximal to the receptor. This review summarizes the current literature that deals with lipid raft involvement in T-cell activation and places particular emphasis in recent studies investigating lipid rafts in autoimmunity. The potential of lipid rafts as targets for the development of a new class of immune-modulating compounds is discussed.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2008.10.006

Authors: Panagiotis S. Kabouridis, Elizabeth C. Jury

Institutions: University of London, Queen Mary University of London, William Harvey Research Institute, The Royal Free Hospital, University College London

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,980