Work

Deuterium Isotope Effect on Excited-State Dynamics in an Alternating GC Oligonucleotide

Year: 2009

Type: article

Abstract: Isotope effects on the excited-state dynamics of single- and double-stranded GC-containing DNAs were studied by femtosecond transient absorption spectroscopy. A pronounced deuterium isotope effect was observed in alternating d(GC)(9).d(GC)(9), but none was seen in the nonalternating or single-stranded variations investigated. These findings demonstrate that an interstrand process involving proton-coupled electron transfer contributes to the excited-state dynamics in DNAs having an appropriate base sequence.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja9076364

Authors: Kimberly de La Harpe, Carlos E. Crespo-Hernández, Bern Kohler

Institution: The Ohio State University

Language: English

Topic: Photochemistry and Electron Transfer Studies

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, Division of Chemistry

Award: Ultrafast Photodynamics of Nucleic Acids