Work

In Vivo T Regulatory Cell Kinetics Are Altered in a Pre-Clinical Model of Chronic Graft-Versus-Host Disease

Year: 2014

Type: article

Abstract: Chronic graft-versus-host disease (cGVHD) is the main cause of late morbidity and non-relapse mortality after allogeneic hematopoietic stem cell transplantation (AHSCT). T cells are known modulators of cGVHD, while their in vivo kinetics, as defined by cell division, cell death and trafficking, remain largely uncharacterized, and current therapies for cGVHD target T cell proliferation. T regulatory cells (T regs) are of particular interest in cGVHD as adoptive transfer or in vivo expansion of this cell type has resulted in amelioration of cGVHD severity in pre-clinical models and in patients with cGVHD.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.052