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Magnesium Deficiency and Hypertension: Correlation Between Magnesium-Deficient Diets and Microcirculatory Changes in Situ

Year: 1984

Type: article

Abstract: Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.

Source: Science

DOI: 10.1126/science.6701524

Authors: Burton M. Altura, Bella T. Altura, Asefa Gebrewold, Hartmut Ising, Theo Gunther

Institutions: State University of New York, SUNY Downstate Health Sciences University, Federal Government of Germany, Freie Universität Berlin

Language: English

Topic: Magnesium in Health and Disease

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2043192013

FWCI: 22.87

Cites: 40

Cited by: 371

Related to: 10