Work

Pressure-driven laminar flow switching for rapid exchange of solution environment around surface adhered biological particles

Year: 2010

Type: article

Abstract: This paper describes a technique for rapidly exchanging the solution environment near a surface by displacing laminar flow fluid streams using sudden changes in applied pressure. The method employs off-chip solenoid valves to induce pressure changes, which is important in keeping the microfluidic design simple and the operation of the system robust. The performance of this technique is characterized using simulation and validated with experiments. This technique adds to the microfluidic tool box that is currently available for manipulating the solution environment around biological particles and molecules.

Source: Lab on a Chip

DOI: 10.1039/b919639k

Authors: Peter B. Allen, Graham Milne, Byron R. Doepker, Daniel T. Chiu

Institution: University of Washington

Language: English

Topic: Microfluidic and Capillary Electrophoresis Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G1505296314, G1897610108, G600972088, G6819848334