Work

Assessing interactions for fixed‐dose drug combinations in subcutaneous tumor xenograft studies

Year: 2013

Type: article

Abstract: Drug combinations in preclinical tumor xenograft studies are often assessed using fixed doses. Assessing the joint action of drug combinations with fixed doses has not been well developed in the literature. Here, an interaction index is proposed for fixed-dose drug combinations in a subcutaneous tumor xenograft model. Furthermore, a bootstrap percentile interval of the interaction index is also developed. The joint action of two drugs can be assessed on the basis of confidence limits of the interaction index. Tumor xenograft data from actual two-drug combination studies are analyzed to illustrate the proposed method.

Source: Pharmaceutical Statistics

DOI: 10.1002/pst.1559

Author: Jianrong Wu

Institution: St. Jude Children's Research Hospital

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Lebanese Syrian Associated Charities, National Institutes of Health, National Cancer Institute