Work

Fibroblast-growth-factor receptor mutations in human skeletal disorders

Year: 1995

Type: review

Abstract: Fibroblast-growth-factor receptors (FGFRs), members of the tyrosine-kinase receptor family, play a crucial role in signal transduction and development. Recently, unique mutations in three human FGFR-encoding genes (FGFR1-3) have been identified as the cause of a variety of skeletal disorders. Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these receptors in normal and abnormal bone development.

Source: Trends in Genetics

DOI: 10.1016/s0168-9525(00)89088-5

Authors: Maximilian Muenke, Ute Schell

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030