Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
Year: 2012
Type: article
Study design: Observational Study
Abstract: Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 3-30%; p(trend) = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 36-7%, p(trend) = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.
Source: International Journal of Cancer
DOI: 10.1002/ijc.27643
Authors: Naomi E. Allen, Paul N. Appleby, Timothy J. Key, H.B. Bueno‐de‐Mesquita, Martine M. Ros, Lambertus A.L.M. Kiemeney, Anne Tjønneland, Nina Roswall, Kim Overvad, Steffen Weikert, Heiner Boeing, Jenny Chang‐Claude, Birgit Teucher, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Sabina Sieri, Petra Peeters, Jose Ramón Quirós, Paula Jakszyn, Esther Molina‐Montes, María‐Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Kay‐Tee Khaw, Nick Wareham, Börje Ljungberg, Göran Hallmans, Roy Ehrnström, Ulrika Ericson, Inger Torhild Gram, Christine L. Parr, Antonia Trichopoulou, Tina Karapetyan, Vardis Dilis, Françoise Clavel‐Chapelon, Marie‐Christine Boutron‐Ruault, Guy Fagherrazzi, Isabelle Romieu, Marc J. Gunter, Elio Riboli
Institutions: University of Oxford, University Medical Center Utrecht, National Institute for Public Health and the Environment, Radboud University Nijmegen, Radboud University Medical Center, Danish Cancer Society, Aarhus University, German Institute of Human Nutrition, Stiftung Charité, Charité – Universitätsmedizin Berlin, German Cancer Research Center, Federico II University Hospital, University of Naples Federico II, Italian institute for Genomic Medicine, Piedmont Reference Center for Epidemiology and Cancer Prevention, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Imperial College London, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Basque Government, University of Cambridge, MRC Epidemiology Unit, Umeå University, Skåne University Hospital, Lund University, UiT The Arctic University of Norway, University of Oslo, National and Kapodistrian University of Athens, Hellenic Health Foundation, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Centre international de recherche sur le cancer
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Stroke Association, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Stavros Niarchos Foundation, Deutsche Krebshilfe, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund
Award: G6957823285
OpenAlex ID: W2043582058