Work

Asymmetric oscillation of adherent targeted ultrasound contrast agents

Year: 2005

Type: article

Abstract: With a lipid shell containing biotin, micron-sized bubbles bound to avidin on a porous and flexible cellulose boundary were insonified by ultrasound. The oscillation of these targeted microbubbles was observed by high-speed photography and compared to the oscillation of free-floating microbubbles. Adherent microbubbles were observed to oscillate asymmetrically in the plane normal to the boundary, and nearly symmetrically in the plane parallel to the boundary, with a significantly smaller maximum expansion in each dimension for bound than free bubbles. With sufficient transmitted pressure, a jet was produced traveling toward the boundary.

Source: Applied Physics Letters

DOI: 10.1063/1.2061872

Authors: Shukui Zhao, Katherine W. Ferrara, Paul A. Dayton

Institution: University of California, Davis

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Engineering approaches to molecular imaging, Ultrasound imaging and local drug delivery in tumors, TARGETED ULTRASOUND IMAGING OF TUMORS