Work

Imaging and Nanomedicine in Inflammatory Atherosclerosis

Year: 2014

Type: review

Abstract: Bioengineering provides unique opportunities to better understand and manage atherosclerotic disease. The field is entering a new era that merges the latest biological insights into inflammatory disease processes with targeted imaging and nanomedicine. Preclinical cardiovascular molecular imaging allows the in vivo study of targeted nanotherapeutics specifically directed toward immune system components that drive atherosclerotic plaque development and complication. The first multicenter trials highlight the potential contribution of multimodality imaging to more efficient drug development. This review describes how the integration of engineering, nanotechnology, and cardiovascular immunology may yield precision diagnostics and efficient therapeutics for atherosclerosis and its ischemic complications.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.3005101

Authors: Willem J. M. Mulder, Farouc A. Jaffer, Zahi A. Fayad, Matthias Nahrendorf

Institutions: Amsterdam UMC Location University of Amsterdam, Icahn School of Medicine at Mount Sinai, Harvard University, Massachusetts General Hospital, Center for Systems Biology

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: ZonMw, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering