Work

Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir

Year: 1994

Type: article

Abstract: Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount in infected, untreated cells. The inhibition of TK production by IFN-alpha treatment appeared to be transient and translational, not transcriptional.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.38.4.853

Authors: J L Taylor, P Tom, J Guy, R M Selvarajan, W J O'Brien

Institution: Medical College of Wisconsin

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Research to Prevent Blindness, National Institutes of Health, National Eye Institute