Year: 2005
Type: article
Abstract: Acute and chronic heart failure (HF) are multi-organ and -cell syndromes characterized by myocardial structural and functional abnormalities, excessive vascular dysfunction and vasoconstriction, avid sodium retention, and neurohumoral maladaptations. In this syndrome, the cGMP pathway may be disrupted, either with impaired production of nitric oxide or its excessive degradation, thus impairing the soluble guanylate cyclase (sGC) signaling pathway or inadequate release of particulate guanylate cyclase (PGC) ligands such as the natriuretic peptide ANP or BNP or the release of abnormal forms, therefore impairing the PGC pathway.
Source: BMC Pharmacology
Authors: John C Burnett, Guido Boerrigter
Institution: Mayo Clinic
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2043860725