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Nuclear Receptor Rev-Erbα: A Heme Receptor that Coordinates Circadian Rhythm and Metabolism

Year: 2010
Type: review
Abstract: Nuclear receptor Rev-erbalpha (NR1D1), previously considered to be an orphan nuclear receptor, is a receptor for heme, which promotes transcriptional repression via recruitment of the NCoR-HDAC3 corepressor complex. Rev-erbalpha gene regulation is circadian, and Rev-erbalpha comprises a critical negative limb of the core circadian clock by directly repressing the expression of the positive clock component, Bmal1. Rev-erbalpha also regulates the metabolic gene pathway, thus serving as a heme sensor for coordination of circadian and metabolic pathways.
DOI: 10.1621/nrs.08001
Language: English
Open Access status: hybrid
Awards: Biology of REV-ERB nuclear receptors, G3032035755, G3119956676, G4617519846, Biology of nuclear receptor Rev-erb alpha in circadian rhythm and metabolism, Nuclear Receptors and Coregulators in Health and Disease, Biology of nuclear receptor rev-erb alpha in circadian rhythm and metabolism
OpenAlex ID: W2043869660
FWCI: 1.289
Cites: 81
Cited by: 142
Related to: 10