Work

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

Year: 2013

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm301431y

Authors: Xun Zhao, Dagart Allison, Bradley Condon, Feiyu Zhang, Tarun Gheyi, Aiping Zhang, Sheela Ashok, Marijane Russell, Iain MacEwan, Yuewei Qian, James A. Jamison, John Gately Luz

Institution: Eli Lilly (United States)

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: U.S. Department of Energy, Office of Science, Basic Energy Sciences, Argonne National Laboratory

OpenAlex ID: W2043901123

FWCI: 9.947

Cites: 39

Cited by: 225

Related to: 10