Work

Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression

Year: 2012

Type: article

Abstract: Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology.

Source: OncoImmunology

DOI: 10.4161/onci.19334

Authors: Scott I. Abrams, Jeremy D. Waight

Institution: Roswell Park Comprehensive Cancer Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913