Psychotic like experiences and 22q11 microdeletion syndrome: two possible models for the investigation of gene-enviroment interaction in psychotic onset
Year: 2013
Type: dissertation
Abstract: Psychotic disorders can be defined as disorders of adaptation to social context. Although heritability is often emphasized, onset must be considered as the end-point of a pathway which involves: 1) genetic heritability; 2) environmental factors; 3) psychopathological factors. \nTherefore, the current challenge consists in combining different scientific fields aiming at a deeper comprehension of psychotic disorders. \n \nTaking off these considerations, this thesis will present research conducted in Rome (Children Hospital Bambino Gesù) and in Birmingham (Department of Psychology, University of Birmingham) by the Author during his PhD. These research are focused on two possible models which can help to better understand the role played by gene/enviroment interaction in the pathogenesis of psychotic disorders. \n \nThe first model concerns the so-called psychotic-like experiences and is therefore situated in the sphere of the psychopathological factors involved in the pathway to psychosis. The second model concerns 22q11 microdeletion syndrome, a genetic syndrome with high prevalence of psychotic disorders. \n \nThe thesis starts with a comprehensive review of these topics. Subsequently, the main findings of the research conducted during the PhD will be described and analyzed. \nImplications are explored, in terms of clinical practice, aetiological pathways, potential treatments and intervention strategies. \n
Author: Marco Armando
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W204405002