Work

Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies

Year: 2012

Type: letter

Abstract: CD47 is a receptor for the secreted protein thrombospondin-1 and a counterreceptor for two members of the signal regulatory protein (SIRP) family. These interactions play important roles in hemostasis, cardiovascular pathophysiology, ischemic injuries, inflammation, radiation injuries, and cancer. Correspondingly, antibodies that block thrombospondin-1 or SIRPα binding and antisense oligonucleotide analogs that suppress CD47 expression have shown efficacy in treating rodent and porcine models of these diseases.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1205441109

Authors: David R. Soto-Pantoja, Thomas W. Miller, William A. Frazier, David D. Roberts

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research, Washington University in St. Louis

Language: English

Topic: Phagocytosis and Immune Regulation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2044062220

Cites: 5

Cited by: 25

Related to: 10