Work

The molecular biology of apoptosis.

Year: 1996

Type: article

Abstract: All multicellular organisms have mechanisms for killing their own cells, and use physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a morphologically recognizable form of cell death that is implemented by a mechanism that has been conserved throughout evolution from nematode to man. Thus homologs of the genes that implement cell death in nematodes also do so in mammals, but in mammals the process is considerably more complex, involving multiple isoforms of the components of the cell death machinery. In some circumstances this allows independent regulation of pathways that converge upon a common end point. A molecular understanding of this mechanism may allow design of therapies that either enhance or block cell death at will.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.6.2239

Authors: D L Vaux, A Strasser

Institutions: The Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2044117808

FWCI: 35.56

Cites: 123

Cited by: 952

Related to: 10