Work

Interaction between the left‐handed Z‐DNA and polyamine The crystal structure of the d(CG)3 and N‐(2‐aminoethyl)‐1,4‐diamino‐butane complex

Year: 1991

Type: article

Abstract: The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24], a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 A resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

Source: FEBS Letters

DOI: 10.1016/0014-5793(91)80694-x

Authors: Hirofumi Ohishi, Shoko Kunisawa, Gijs van der Marel, Jacques H. van Boom, Alexander Rich, Andrew H.-J. Wang, Ken-ichi Tomita, Toshio Hakoshima

Institutions: Osaka University of Pharmaceutical Sciences, The University of Osaka, Leiden University, Massachusetts Institute of Technology, University of Illinois Urbana-Champaign

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2044133323

FWCI: 0.132

Cites: 13

Cited by: 30

Related to: 10