Work

A Synthesis of the Carbocyclic Core of Maoecrystal V

Year: 2010

Type: article

Abstract: An approach toward the synthesis of the complex polycyclic diterpene maoecrystal V (1) is described. Construction of the advanced tetracyclic core structure (i.e., 19) was achieved in 13 steps from 3,3-dimethylcyclohexanone (6) by employing a stereoselective Nazarov cyclization followed by a Diels-Alder reaction to forge the two contiguous quaternary stereocenters.

Source: Organic Letters

DOI: 10.1021/ol101025r

Authors: Kiel E. Lazarski, Dennis X. Hu, Charlotte L. Stern, Regan J. Thomson

Institution: Northwestern University

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging

Award: Drug Discovery Training in Age-Related Disorders