Work

Estradiol binding in the sexually dimorphic nucleus of the preoptic/anterior hypothalamic area of adult male ferrets and in the equivalent region of females

Year: 1991

Type: article

Abstract: A large number of estradiol-concentrating cells were visualized by autoradiography in a subpopulation of large neurons located in and around the sexually dimorphic male nucleus of the preoptic/anterior hypothalamic area (MN-POA/AH) of castrated male ferrets and in a comparable dorsal portion of the POA/AH of ovariectomized females. Considerably fewer estradiol-labelled cells were seen in the non-dimorphic ventral POA/AH nucleus of both sexes. Estrogen binding in cells in or around the MN-POA/AH may contribute to the formation of this sexually dimorphic nucleus in fetal males and may mediate specific estrogen-dependent behavioral functions in adulthood.

Source: Brain Research

DOI: 10.1016/0006-8993(91)91500-z

Authors: S.A. Tobet, M.J. Baum

Institutions: Boston University, Harvard University

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360