Work

Circulating Blasts Following Chemotherapy in Pediatric Patients: Implications for Complete Remission Definition in Acute Leukemia

Year: 2003

Type: article

Abstract: We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC>1.5x10(9)/l in 13 of 30 (43%) samples, and platelets >100x10(9)/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

Source: Hematology

DOI: 10.1080/10245330310001604737

Authors: Mihaela Onciu, Elihu Estey, Francis J. Giles

Institutions: St. Jude Children's Research Hospital, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2044409417

FWCI:

Cites: 26

Cited by: 1

Related to: 10