Year: 2008
Type: article
Abstract: The gene dosage balance hypothesis states that a concentration imbalance among components of macromolecules is often deleterious. Thus this notion potentially provides a mechanistic explanation for understanding genetic dominance and gene duplicability. Accumulating evidence emerged from recent genomic data has strongly supported this hypothesis. Further efforts are needed to understand dosage sensitivity in the context of organismal complexity and co-regulation of genes under dosage-balance constraints.
Source: Frontiers in bioscience
DOI: 10.2741/3010
Author: Han Liang
Institution: University of Chicago
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W204478013