Work

Niche competition and cancer metastasis to bone

Year: 2011

Type: article

Abstract: The molecular basis for the preferential metastases of certain cancers to bone is not well understood. In this issue of the JCI, Shiozawa et al. provide compelling evidence that prostate cancer cells preferentially home to the osteoblastic niche in the bone marrow, where they compete with normal HSCs for niche support. Because signals from the niche may regulate tumor quiescence and sensitivity to chemotherapy, these observations have important implications for the treatment of metastatic prostate cancer in bone.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci57229

Authors: Laura G. Schuettpelz, Daniel C. Link

Institution: Washington University in St. Louis

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Leona M. and Harry B. Helmsley Charitable Trust, National Institutes of Health