Work

Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications

Year: 2011

Type: article

Abstract: Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 ((68)Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile "clickable" zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.

Source: Langmuir

DOI: 10.1021/la2000409

Authors: Nicholas Ndiege, Renugan Raidoo, Michael K. Schultz, Sarah Larsen

Institution: University of Iowa

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources

Awards: G4589373271, G77050141