Work

Nickel-Catalyzed Amination of Aryl Sulfamates and Carbamates Using an Air-Stable Precatalyst

Year: 2012

Type: article

Abstract: A facile nickel-catalyzed method to achieve the amination of synthetically useful aryl sulfamates and carbamates is reported. Contrary to most Ni-catalyzed amination reactions, this user-friendly approach relies on an air-stable Ni(II) precatalyst, which, when employed with a mild reducing agent, efficiently delivers aminated products in good to excellent yields. The scope of the method is broad with respect to both coupling partners and includes heterocyclic substrates.

Source: Organic Letters

DOI: 10.1021/ol301847m

Authors: Liana Hie, Stephen D. Ramgren, Tehetena Mesganaw, Neil K. Garg

Institution: University of California, Los Angeles

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Amgen, AstraZeneca, National Center for Research Resources

Award: Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical Research