Work

Latency Locus Complements MicroRNA 155 Deficiency In Vivo

Year: 2013

Type: article

Abstract: MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155.

Source: Journal of Virology

DOI: 10.1128/jvi.01620-13

Authors: Sang-Hoon Sin, Yong Baek Kim, Dirk P. Dittmer

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Seoul National University

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute