Year: 2014
Type: review
Abstract: Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of pathological matrix in the interstitial space and within the walls of glomerular capillaries as well as the cellular processes resulting in this deposition are increasingly recognized as important factors amplifying kidney injury and accelerating nephron demise. Recent insights into the cellular and molecular mechanisms of fibrogenesis herald the promise of new therapies to slow kidney disease progression. This review focuses on new findings that enhance understanding of cellular and molecular mechanisms of fibrosis, the characteristics of myofibroblasts, their progenitors, and molecular pathways regulating both fibrogenesis and its resolution.
DOI: 10.1172/jci72267
Author: Jeremy S. Duffield
Institutions: Biogen (United States), University of Washington
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: American Heart Association, Eli Lilly and Company, Biogen, University of Washington, National Institutes of Health, University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1920715077, Kidney pericytes in vascular regeneration after injury, A Tissue Engineered Human Kidney Microphysiological System, A Tissue Engineered Human Kidney Microphysiological System, Kidney Progenitor Cells in Disease, G5144902905, Pericyte-endothelial cross talk in vascular stability after kidney injury, G6246106196, G6302904578, G6412111073, G7474898795, G8096162905, G9000035578, Diabetes Research Center
OpenAlex ID: W2044982400