Work

Gold-Catalyzed Oxidative Coupling Reactions with Aryltrimethylsilanes

Year: 2010

Type: article

Abstract: During continuing studies with a novel oxidative gold oxyarylation reaction, arylsilanes were found to be competent coupling partners, providing further evidence for an intramolecular electrophilic aromatic substitution mechanism. While providing yields complementary to those of the previously described boronic acid methods, the use of trimethylsilanes reduces the observation of homocoupling byproducts and allows for facile intramolecular coupling reactions.

Source: Organic Letters

DOI: 10.1021/ol102194c

Authors: William E. Brenzovich, Jean-François Brazeau, F. Dean Toste

Institution: University of California, Berkeley

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation