Work

Site-directed mutagenesis of mouse thymidylate synthase: Alteration of Arg 44 to Val 44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding

Year: 1990

Type: article

Source: Biochemical and Biophysical Research Communications

DOI: 10.1016/0006-291x(90)90604-l

Authors: Haichao Zhang, Ralph J. Cisneros, Wanleng Deng, Lee F. Johnson, R.Bruce Dunlap

Institutions: The Ohio State University, University of South Carolina

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G2714647962, G4531782395, G5124175904, DTMP SYNTHASE: NMR AND MECHANISTIC STUDIES, THYMIDYLATE SYNTHASE GENE EXPRESSION, Cancer Center Support Grant

OpenAlex ID: W2045175745

FWCI: 0.428

Cites: 13

Cited by: 8

Related to: 10