On the Origin of Bacterial Resistance to Penicillin: Comparison of a β-Lactamase and a Penicillin Target
Year: 1986
Type: article
Abstract: Structural data are now available for comparing a penicillin target enzyme, the D-alanyl-D-alanine-peptidase from Streptomyces R61, with a penicillin-hydrolyzing enzyme, the beta-lactamase from Bacillus licheniformis 749/C. Although the two enzymes have distinct catalytic properties and lack relatedness in their overall amino acid sequences except near the active-site serine, the significant similarity found by x-ray crystallography in the spatial arrangement of the elements of secondary structure provides strong support for earlier hypotheses that beta-lactamases arose from penicillin-sensitive D-alanyl-D-alanine-peptidases involved in bacterial wall peptidoglycan metabolism.
Source: Science
Authors: J. A. Kelly, O. Dideberg, P. Charlier, J. P. Wery, M. Libert, P. C. Moews, J. R Knox, C. Duez, Cl. Fraipont, B. Joris, J. Dusart, J. M. Frère, J. M. Ghuysen
Institutions: University of Connecticut, University of Liège
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: green
Awards: G1477614463, G2686100561, G929027141
OpenAlex ID: W2045301115