Work

Transforming Suzuki–Miyaura Cross-Couplings of MIDA Boronates into a Green Technology: No Organic Solvents

Year: 2013

Type: article

Abstract: New technology has been developed that enables Suzuki-Miyaura couplings involving widely utilized MIDA boronates to be run in water as the only medium, mainly at room temperature. The protocol is such that no organic solvent is involved at any stage; from the reaction through to product isolation. Hence, using the E factor scale as a measure of greenness, the values for these cross-couplings approach zero.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja409663q

Authors: Nicholas A. Isley, Fabrice Gallou, Bruce H. Lipshutz

Institutions: University of California, Santa Barbara, Novartis (Switzerland)

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funder: National Institute of General Medical Sciences