Work

Effect of Estrogen on the Response of Thyroid Stimulating Hormone to Substance P in Rats.

Year: 1989

Type: article

Abstract: The role of substance P (SP) in the control of thyroid stimulating hormone (TSH) release and the influence of gonadal steroid were investigated. Intravenous administration of SP failed to alter plasma levels of TSH in ovariectomized (OVX) rats, whereas SP induced a significant increase in plasma TSH in estradiol benzoate-primed (Eb-primed) OVX rats (P less than 0.001). Further, intravenously administered SP did not affect the plasma TSH concentration in normal male rats, but significantly increased it in Eb-primed castrated male rats (P less than 0.01). These data suggest possible roles for SP at the level of the hypothalamus and/or the pituitary gland in stimulating TSH secretion under the influence of estrogen.

Source: Endocrinologia Japonica

DOI: 10.1507/endocrj1954.36.899

Authors: MASAYOSHI ARISAWA, TSUNEHISA MAKINO, SAMUEL M. MCCANN, RIHACHI IIZUKA

Institutions: Keio University, The University of Texas Southwestern Medical Center

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2045369870

FWCI:

Cites: 11

Cited by: 6

Related to: 10