Work

Neurotransmitter release — four years of SNARE complexes

Year: 1997

Type: review

Abstract: Exocytosis in neurons requires proteins known as SNAREs, membrane proteins that have now been implicated in many intracellular fusion events. SNAREs assemble into stable ternary complexes that are dissociated by the ATPase NSF (N-ethylmaleimide-sensitive factor), working together with SNAPs (soluble NSF attachment proteins). Recent results have shed new light on the mechanisms underlying SNARE (SNAP receptor) complex assembly and disassembly, and suggest changes in models that relate these reactions to vesicle docking and fusion.

Source: Current Opinion in Neurobiology

DOI: 10.1016/s0959-4388(97)80057-8

Authors: Phyllis I Hanson, John E Heuser, Reinhard Jahn

Institutions: Yale University, Washington University in St. Louis

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,320

Funder: Helen Hay Whitney Foundation