Work

Angiogenesis and the Tumor Microenvironment: Vascular Endothelial Growth Factor and Beyond

Year: 2014

Type: article

Abstract: Our understanding of the dynamic tumor microenvironment (TME) has improved exponentially over the last few decades. In addition to traditional cytotoxic agents, anti-cancer strategies now include numerous molecular-targeted drugs that modulate distinct elements of the TME. Angiogenesis is an underlying promoter of tumor growth, invasion, and metastases. From traditional and emerging angiogenic cytokines and their receptors to novel immune checkpoint inhibitors, regulation of the tumor microenvironment is potentially key in countering tumor progression. In this article, an overview of the architecture of the TME and the orchestration of angiogenesis within the TME is provided. Additionally, traditional and novel angiogenic targets of current interest within the TME are reviewed.

Source: Seminars in Oncology

DOI: 10.1053/j.seminoncol.2014.02.007

Authors: Kriti Mittal, John Ebos, Brian Rini

Institutions: Cleveland Clinic, Case Comprehensive Cancer Center, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550