Work

Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke

Year: 2012

Type: article

Abstract: It has been more than a century since Paul Ehrlich, in 1885, and later his student Edwin Goldmann, proposed that a barrier existed between the CNS and the peripheral circulation. 1 While studying the limited permeation of potassium ferrocyanate into the brain in 1900, Lewandowsky coined the term bluthirnschranke, blood-brain barrier (BBB). 1 The BBB is considered the gatekeeper of the CNS, whose main role is to maintain the fragile homeostasis of the brain designed by segregating the CNS from the systemic circulation.

Source: Neurology

DOI: 10.1212/wnl.0b013e3182697e70

Authors: Rakesh Khatri, Alexander M. McKinney, Barbara Swenson, Vallabh Janardhan

Institution: University of Minnesota

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2045445343