Work

p53 mediates interstitial cystitis antiproliferative factor (APF)‐induced growth inhibition of human urothelial cells

Year: 2007

Type: article

Abstract: Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis, a urinary bladder disorder of unknown etiology that is characterized by chronic pelvic pain. The present study was directed toward uncovering a pathway through which APF signals. Treatment of human urothelial cells with native APF resulted in growth inhibition accompanied by blockade of cell cycle transit and increased p53. Reduced expression of p53 by RNA interference diminished, while ectopic expression of p53 mimicked, the effects of APF. These are the first findings implicating the network of p53 target genes in urothelial defects associated with interstitial cystitis.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2007.06.058

Authors: Jayoung Kim, Susan K. Keay, Jordan D. Dimitrakov, Michael R. Freeman

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases