Work

Exploiting Synergy: Immune-Based Combinations in the Treatment of Prostate Cancer

Year: 2014

Type: article

Abstract: Cancer treatment is being revolutionized by the emergence of immunotherapies such as immune checkpoint inhibitors and therapeutic cancer vaccines. Prostate cancer is amenable to such therapeutic approaches. The improved understanding of the relationship between the immune system and tumors has allowed therapeutic targeting of immune checkpoints and tumor associated antigens to be developed. Furthermore, interventions used in prostate cancer are capable of impacting the immune system. As demonstrated by preclinical data and emerging clinical data, radiation therapy, anti-androgen therapy, and chemotherapy can be used with immunotherapies to obtain synergistic results. Current and future clinical trials will further investigate these principles as immunotherapeutics are combined with each other and standard therapies for optimal clinical utility.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2014.00351

Authors: Mauricio Burotto, Nishith Singh, Christopher R. Heery, James L. Gulley, Ravi A. Madan

Institutions: National Institutes of Health, National Cancer Institute, Indiana University Health

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801