Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
Year: 1976
Type: article
Abstract: A C T During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxy- tryptamine from indomethacin-treated platelets.By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material.This material persists in plasma because of its contintued production and increased stability.in aqueous medium of 32+2 s (4).Evidence was presented that thromboxane A2 induces irreversible platelet aggregation and causes the release of sero- Part of this work was presented at the Fall Meeting, American Oil Chemists Society, 1974, Philadelphia, Pa.
DOI: 10.1172/jci108564
Authors: J B Smith, C Ingerman, M J Silver
Institution: Thomas Jefferson University
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2045564722