Work

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

Year: 1986

Type: article

Abstract: We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.83.7.2157

Authors: R T Schimke, S W Sherwood, A B Hill, R N Johnston

Institutions: University of Arizona, University of Calgary, Stanford University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences