Year: 2014
Type: article
Abstract: Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.
Source: Journal of Neuroscience
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: Multimodal Functional Imaging of Auditory Perception Under General Anesthesia, A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia, A Systems Neuroscience Approach for the Study of General Anesthesia, Dynamic Inverse Solutions for Multimodal Imaging, Global cortical dynamics in sleep and general anesthesia, Dynamic Analyses of Learning in Behavioral Experiments
OpenAlex ID: W2045823870