Work

gamma-Aminobutyric acid antagonists decrease junctional communication between L-horizontal cells of the retina.

Year: 1982

Type: article

Abstract: The antagonists of gamma-aminobutyric acid, bicuculline and picrotoxin, were found to narrow the receptive field profile of the large field horizontal cell (L1HC) in the turtle retina when added to the perfusion medium in micromolar concentrations. The coupling resistance between neighboring L1HCs was increased by bicuculline or picrotoxin. Under control conditions, the dye Lucifer yellow injected into one L1HC diffused into a large number of neighboring L1HCs; bicuculline or picrotoxin greatly restricted dye passage between these same cells. We conclude that antagonists of gamma-aminobutyric acid decrease the conductance of gap junctions between L1HCs.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.79.11.3671

Authors: M Piccolino, J Neyton, P Witkovsky, H M Gerschenfeld

Institutions: Scuola Normale Superiore, NYU Langone Health, National Research Council, New York University

Language: English

Topic: Connexins and lens biology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Centre National de la Recherche Scientifique