Measurement of NMDA receptor antagonist, CPP, in mouse plasma and brain tissue following systemic administration using ion-pair LC-MS/MS
Year: 2014
Type: article
Abstract: ) of CPP was 8.8 minutes in plasma and 14.3 minutes in brain tissue, and the plasma to brain concentration ratio was about 18:1. This pharmacokinetic data will aid the interpretation of the vast number of studies using CPP to investigate NMDA receptor function in rodents and the method itself can be used to study many other highly polar analytes of interest.
Source: Analytical Methods
DOI: 10.1039/c4ay01168f
Institution: University of Wisconsin–Madison
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, Wisconsin Alumni Research Foundation, University of Wisconsin-Madison, National Institute for Health and Care Research, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W2045912113