Work

Substance P antagonists in substantia nigra are anticonvulsant

Year: 1986

Type: article

Abstract: Bilateral intranigral microinfusion of antagonist analogs of substance P significantly attenuated convulsions induced by maximal electroshock or intravenous bicuculline in rats. Infusions of substance P antagonists placed adjacent to the substantia nigra in the vicinity of the lateral hypothalamus were without anticonvulsant action. Our data indicate an as yet undescribed role for substance P antagonists in the regulation of seizure susceptibility, and provide additional evidence that decreasing the activity of substantia nigra outputs is anticonvulsant.

Source: Brain Research

DOI: 10.1016/0006-8993(86)91347-8

Authors: Douglas S. Garant, Michael J. Iadarola, Karen Gale

Institutions: Georgetown University, National Institutes of Health, National Institute of Dental and Craniofacial Research

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360