Work

Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis

Year: 2008

Type: article

Abstract: Abyssomicin C is a recently discovered antibiotic with promising antibacterial activity, high structural complexity, and a novel mechanism of action. We give an account of our abyssomicin campaign and some of the discoveries that were borne of our total synthesis efforts, including a new Lewis acid-templated Diels-Alder reaction, the previously undescribed atrop-abyssomicin C, a facile Brønsted acid-catalyzed isomerization of abyssomicin C, and clarification of the likely biosynthetic origin of abyssomicin D.

Source: Synthesis

DOI: 10.1055/s-0028-1083259

Authors: K. Nicolaou, Scott Harrison, Jason Chen

Institutions: Scripps Research Institute, University of California San Diego

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Synthesis of Anti-Infective Agents