Work

Antigen-dependent suppression of graft versus host disease by Foxp3-induced regulatory T cells in transplantation

Year: 2006

Type: article

Abstract: Adoptive transfer of polyclonal CD4+CD25+ regulatory T cells (Tregs) can tolerize transplantation alloresponses and prevent lethal acute graft-versus-host disease (GVHD). For optimal suppressive function, Tregs need to be activated via their T-cell receptors (TCR), but the antigen specificity of wild type Tregs remains elusive, and therefore controlling potency and duration of Treg activity in the transplantation setting remains not feasible. In this study, we used a murine lethal acute GVHD model system to test the hypothesis that specifically activated, antigen-specific Tregs induced by foxp3 transduction could suppress the response of T effector cells to alloantigens in vitro and prevent GVHD in vivo more effectively than polyclonal Tregs.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.017

Authors: M.H. Albert, Y. Liu, C. Anasetti, X.-Z. Yu

Institutions: München Klinik, University of Washington, Moffitt Cancer Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650