Work

Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin

Year: 1992

Type: article

Abstract: Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated P. aeruginosa 579 biofilms and fluids distal to a viable P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.36.9.2054

Authors: B D Hoyle, J Alcantara, J W Costerton

Institution: University of Calgary

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2046267646

FWCI: 0.782

Cites: 18

Cited by: 165

Related to: 9