Work

Molecular and functional aspects of PECAM-1/CD31

Year: 1994

Type: review

Abstract: Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.

Source: Immunology Today

DOI: 10.1016/0167-5699(94)90195-3

Authors: Horace M. DeLisser, Peter J. Newman, Steven M. Albelda

Institutions: University of Pennsylvania Health System, University of Pennsylvania, Medical College of Wisconsin, The Wistar Institute

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, Medical College of Wisconsin, National Heart, Lung, and Blood Institute