Work

Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity

Year: 2014

Type: review

Abstract: In 1979, the seminal work of Wenkert set the standards for the utilization of aryl and vinyl ethers as coupling partners via C-O bond-cleavage. Although the topic remained dormant for almost three decades, the last few years have witnessed a renaissance in this area of expertise, experiencing an exponential growth and becoming a significant discipline within the cross-coupling arena. The means to utilize readily accessible aryl or vinyl ethers as counterparts does not only represent a practical, powerful and straightforward alternative to organic halides, but also constitutes an excellent opportunity to improve our chemical knowledge about a relatively unexplored area of expertise. This review summarizes the most significant developments in the area of C-O bond-cleavage when employing aryl or vinyl ethers, providing a detailed overview of the current state of the art and including future aspects, when applicable.

Source: Chemical Society Reviews

DOI: 10.1039/c4cs00206g

Authors: Josep Cornella, Cayetana Zarate, Ruben Martin

Institutions: Institut Català d'Investigació Química, Institució Catalana de Recerca i Estudis Avançats

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: European Commission, Institut Català d'Investigació Química, European Research Council

Awards: Chasing sustainability: Synthesis of carboxylic acids from simple alcohols via CO2 fixation, G3405840910